Cell-Based Management of Cartilage Defects: A Review
Cartilage injury can be disabling for young and active patients/athletes. These patients often do not regain normal function, and total joint replacement is not the best option for young patients. The current focus is on tissue engineering, scaffolds, and stem cells to form hyaline cartilage that is mechanically functional within cartilage defects. The success of stem cell treatment for animal cartilage defects in vivo is well established. Stem cells have been incorporated for cartilage defect treatment in humans for some time now. Mesenchymal Stem Cells (MSCs) in cartilage repair have shown better outcomes than all available clinical options. Although some issues still need to be addressed, long-term comparative clinical studies of MSCs-based treatments are required before using this technique as the gold standard for cartilage defect treatment.
DOI: 10.29245/2767-5130/2025/4.1233 View / Download Pdf